A substance classified as CMR1B (or CMR1A) is prohibited in many countries from use in cosmetic products. By way of exception, the authorities may adopt measures for the authorization of these categories of substances. For example, in the EU all of the following conditions listed in article 15, paragraph 2 must be fulfilled:
- No suitable alternative substances are available,
- The application is made for a particular use of the product category with a known exposure,
- Assessment by the Scientific Committee for Consumer Safety (SCCS) of the European Commission concluding to the safety for use in cosmetic products.